adipose tissue macrophages going off track during obesity treatment

Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect ...- adipose tissue macrophages going off track during obesity treatment ,Adipose tissue macrophages: going off track during obesity. Diabetologia 59, 879–894. doi: 10.1007/s00125-016-3904-9 PubMed Abstract | CrossRef Full Text | Google ScholarMacrophage Metabolism at the Crossroad of Metabolic ...Jun 12, 2020·Boutens L, Stienstra R. Adipose tissue macrophages: going off track during obesity. Diabetologia. 2016;59(5):879-94. View Article PubMed/NCBI Google Scholar. 15. Haka AS, Barbosa-Lorenzi VC, Lee HJ, Falcone DJ, Hudis CA, Dannenberg AJ, et al. Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.



Macrophages as Key Players during Adipose Tissue ... - Thieme

14 Boutens L, Stienstra R. Adipose tissue macrophages: going off track during obesity. Diabetologia 2016; 59 (05) 879-894 Diabetologia 2016; 59 (05) 879-894 15 Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R. Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic ...

Adipose tissue macrophages: going off track during …

one might hypothesise that the role of macrophages shifts during the progression of obesity from a predominant role in stimu- lating adipogenesis at the start of adipose tissue expansion to inhibitingadipogenesisonceobesityprogresses.theobserva- tion that adipogenic clusters containing macrophages appear at an early stage of adipose tissue …

Regulation of adipogenic differentiation and adipose ...

Jun 05, 2021·Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis.

Properties and functions of adipose tissue macrophages in ...

Sep 19, 2018·During the development of obesity, the number of adipose tissue T cells (ATTs) increases as does the CD8 +-to-CD4 + T-cell ratio, whereas the percentage of T regulatory cells (Tregs) decreases. 87 Both CD4 + and CD8 + T cells are crucial in the recruitment and polarization of ATMs through cytokines such as interferon (IFN)-γ, and the ...

Adipose tissue macrophages: going off track during obesity

Mar 06, 2016·Both conventional and tissue-specific functions of adipose tissue macrophages (ATMs) in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity.

Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity ...

Jul 19, 2018·Introduction. Obesity-induced insulin resistance is tightly associated with increased inflammation in obese white adipose tissue (WAT) as indicated by increased infiltration of multiple types of proinflammatory immune cells into WAT. 1 – 3 Among these cell types, the macrophage is the first type of immune cells identified and plays a crucial role in obesity …

The Composition and Metabolism in Vitro of Adipose Tissue ...

Fat cells of different sizes were isolated from the same sample of adipose tissue by collagenase treatment and fractionation by flotation in an isoosmolar medium. ... Adipose tissue macrophages: going off track during obesity, Diabetologia, 10.1007/s00125-016-3904-9 ... 3 Adipose Tissue, Obesity and Insulin, , 10.1016/S0079-6468(08)70158-9 ...

Repeated clodronate-liposome treatment ... - Physiology

Feb 22, 2019·CLD treatment was initiated after 16 wk of HFD feeding, as we previously showed that 16 wk of HFD feeding induces an obese phenotype, characterized by adipose tissue inflammation with significant adipose tissue macrophage recruitment and metabolic dysfunction (12, 13). PBS-encapsulated liposomes (ClodronateLiposomes) were administered in the ...

Unique metabolic activation of adipose tissue macrophages ...

Jan 14, 2018·Unique metabolic and inflammatory activation in ATMs during obesity. (a) PCA of various tissue macrophages, separated based on their transcriptome.n = 2 for macrophages from peritoneum, small intestine and adipose tissue; n = 1 for other macrophages.Data are derived from GEO accession no. GSE53986. Percentage of explained variance (expl. var.) is …

Adipose tissue macrophages: going off track during obesity

(A TMs) in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity. Furthermore, we will address various...

Human macrophages stimulate expression of inflammatory ...

Mar 01, 2021·Adipose tissue macrophages: going off track during obesity Diabetologia , 59 ( 2016 ) , pp. 879 - 894 , 10.1007/s00125-016-3904 …

Macrophage Populations in Visceral Adipose Tissue from ...

Obesity is associated with inflammatory changes and accumulation and phenotype polarization of adipose tissue macrophages (ATMs). Obese pregnant women have alterations in adipose tissue composition, but a detailed description of macrophage population is not available. In this study, we characterized macrophage populations in visceral adipose tissue (VAT) from …

Glutamine Metabolism in Macrophages: A Novel Target for ...

Macrophages in obesity. Alterations in macrophage function and polarization are associated with various human diseases. Exaggerated or prolonged M1 responses are involved in inflammatory diseases (e.g., sepsis, atherosclerosis, rheumatoid arthritis) and metabolic diseases (e.g., obesity or diabetes) (for reviews see references 32–34).For example, in the white …

Adipose tissue macrophages: going off track during obesity ...

Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean …

Adipose tissue macrophages: going off track during obesity ...

Adipose tissue macrophages: going off track during obesity. Lily Boutens, ... in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity. Furthermore, we will address various circulating and adipose tissue-derived triggers that may be involved in shaping the ATM ...

Peritoneal macrophages have an impaired immune response in ...

Results and conclusions In contrast to the proinflammatory phenotype of adipose tissue macrophages in obesity and T2D, we found a deactivated state of PMs in obesity and T2D. Weight loss could reverse this deactivated macrophage phenotype. Anti-inflammatory characteristics of these non-adipose macrophages may explain why patients with obesity …

The Composition and Metabolism in Vitro of Adipose Tissue ...

Fat cells of different sizes were isolated from the same sample of adipose tissue by collagenase treatment and fractionation by flotation in an isoosmolar medium. ... Adipose tissue macrophages: going off track during obesity, Diabetologia, 10.1007/s00125-016-3904-9 ... 3 Adipose Tissue, Obesity and Insulin, , 10.1016/S0079-6468(08)70158-9 ...

Adipose tissue as an immunological organ - Grant - 2015 ...

Jan 22, 2015·An understanding of adipose tissue leukocytosis began with the identification of macrophages in adipose tissue. Seminal findings by Weisberg et al. and Xu et al. demonstrated that macrophages are increased in adipose tissue during obesity and that macrophages are the primary source of TNF (13, 14).

Repeated clodronate-liposome treatment ... - Physiology

Feb 22, 2019·CLD treatment was initiated after 16 wk of HFD feeding, as we previously showed that 16 wk of HFD feeding induces an obese phenotype, characterized by adipose tissue inflammation with significant adipose tissue macrophage recruitment and metabolic dysfunction (12, 13). PBS-encapsulated liposomes (ClodronateLiposomes) were administered in the ...

TIM4+ adipose tissue-resident macrophages: new modulators ...

Aug 19, 2021·Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4 ...

Increased expression of the macrophage markers and of 11β ...

Apr 24, 2007·To determine whether increased expression of macrophage markers and of inflammatory markers in subcutaneous adipose tissue is associated with liver fat in human obesity. We also determined whether ...

SBP2 deficiency in adipose tissue macrophages drives ...

Aug 14, 2019·Obesity induces chronic inflammation that may cause the development of insulin resistance and its common comorbidity, type 2 diabetes (T2D) ().Inflammation in the adipose tissues, especially in white adipose tissue, predominantly controls insulin resistance ().Adipose tissue macrophages (ATMs) are considered to be the primary regulator of inflammation in …

Distinct macrophage populations direct inflammatory ... - PNAS

May 14, 2018·Macrophages are the predominant immune cell in adipose tissue, and they accumulate in obese mice and humans (3, 4).The increased number of adipose tissue macrophages (ATMs) in obese adipose tissue is in part due to recruitment of peripheral cells (5–7), but local proliferation also plays a role as a subset of ATMs express Ki67 and markers …

Adipose tissue macrophages : going off track during ...

Adipose tissue, Fat, Immune cells, Inflammation, Insulin resistance, Macrophages, Metabolism, Obesity, Review: Language: English: Type: Article: Abstract <p>Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals.

Adipose tissue macrophages: going off track during obesity

Mar 03, 2016·Whereas macrophages in lean mice and humans make up around 5% of the cells in adipose tissue, during obesity they constitute up to 50% of all adipose tissue cells . As well as increasing in number, adipose tissue macrophages (ATMs) change their localisation and inflammatory features during obesity.

Adipose tissue microenvironments during aging: Effects on ...

Lipopolysaccharide treatment reduces contractile responses, ... Adipose tissue macrophages: going off track during obesity. Diabetologia, 59 (2016), pp. 879-894. ... The immune landscape of visceral adipose tissue during obesity and aging. Front. Endocrinol., 11 (2020), p. 267.